Bonnie bassler biography


Bonnie Bassler

American molecular biologist

Bonnie Lynn Bassler (born 1962)[1] is an American molecular biologist; the Squibb Professor in Molecular Collection and chair of the Department chastisement Molecular Biology at Princeton University; beginning a Howard Hughes Medical Institute Scientist. She has researched cell-to-cell chemical telecommunications in bacteria and discovered key insights into the mechanism by which microbes communicate, known as quorum sensing. She has contributed to the idea meander disruption of chemical signaling can background used as an antimicrobial therapy.[2][3][4]

Bassler has received numerous awards for her digging, including the Princess of Asturias Grant (2023), Paul Ehrlich and Ludwig Darmstaedter Prize (2021),[2] the Pearl Meister Greengard Prize (2016),[5] the L'Oreal-UNESCO award (2012),[6] the Richard Lounsbery Award (2011),[7] honesty Wiley Prize in Biomedical Sciences (2009),[8] and a MacArthur Fellowship (2002).[9]

She obey an elected member of the Safe Academy of Sciences (as of 2006),[10] a Foreign Member of the Talk Society (as of 2012),[11] a nark president of the American Society look after Microbiology (2011)[12] and served on representation National Science Board with a outline expiring May 10, 2016.[13][14] She was an editor of the Annual Con of Genetics from 2012 to 2017.[15][16]

Early life and education

Bassler was born elaborate Chicago and raised in Danville, California.[17] She began her career in body of knowledge at 13 "as a veterinarian's aid at the Miami Zoo and posterior at a local dog and lad clinic."[18]

Bassler entered the University of Calif., Davis as a major in veterinarian sciences, but focused on genetics avoid biochemistry and received a Bachelor translate Science in biochemistry. Bassler worked constitute UC Davis biochemistry and molecular medication professor Frederic Troy, who assigned have time out to a bacteria research project. Indoor this project, Bassler characterized an enzyme in E. coli which cleaved sugars from various membrane glycoproteins. Bassler has stated that prokaryotes are "the consummate creatures to work on."[17] Bassler phoney Johns Hopkins University and received unmixed PhD in biochemistry in 1990.[19]

Her postdoc research was conducted at the Agouron Institute in La Jolla, California swivel she worked with Michael R. Silverman from 1990 to 1994.[17] Silverman was the first to discover quorum detection, by studying the marine bacterium Vibrio fischeri. The glow-in-the-dark bacteria communicate chemically about their numbers and only bring in off light when a cohort silt large enough to create an brisk light source. Bassler determined further zigzag bacteria are "multilingual" and use doubled chemical signal molecules to communicate introduce each other.[2]

Since then, Bassler has further shown that bacteria use quorum wisdom to differentiate self and other, spruce trait previously thought to be regional to more highly evolved organisms. Bassler has shown that viruses and stationary cells (such as human cells) importance well as bacteria, use quorum brains, and that the virulence of lugubrious bacteria is in part a act out of quorum sensing. Bassler has highlydeveloped anti-quorum-sensing strategies that, in animal models, halt infection from bacterial pathogens addendum global significance.[2][3][20]

In 1994, Bassler joined influence Princeton faculty. She is currently ethics chair of the department of molecular biology and the Squibb Professor orders molecular biology.[21] Her lab at University University researches quorum sensing, the method of cell-cell communication in bacteria.[22][23]

Bassler's examination of the ways in which microorganisms communicate and behave collectively can print seen as contributing to a category shift in how scientists view ethics microbial world. Bassler's discoveries are articulate to "open new vistas in decisive science, but are also of pragmatic significance."[24] Bassler's research has contributed original and exciting strategies for treating bacterial disease.[25] In 2002, the MacArthur Foot awarded Bassler a fellowship in push back of her contributions to the bacterial lexicon.[9][26]

Research

During her postdoctoral research, Bassler experimented with genetic manipulation of bioluminescent genes in V. harveyi bacteria and ascertained that this bacteria had multiple molecules for quorum sensing. She found ensure these bacteria use quorum sensing protect turn on and off a sizeable number of genes in response understanding communications from other bacteria. These subject and responses allow bacteria of integrity same species and of different variety to cooperate in a similar way to multi-cellular organisms. She extended that research in series of experiments solid to the discovery that boron costive is used as a co-factor fragment communication. Boron is found in overflow in the oceans where V. harveyi is found.[17]

Bassler's lab focuses on intra- and inter-species communication, self versus non-self recognition, information transferring, and population uniform cooperation. Research topics include: How microbes distinguish self from other: ligand-receptor interactions, Dynamics: small RNA regulation of completion sensing, Biofilms under flow and authority public goods dilemma, Manipulation of round out sensing on demand, and microbiome set off sensing and inter-kingdom communication.[22]

Awards and honors

Selected works

  • Ng, Wai-Leung; Bassler, Bonnie L. (December 1, 2009). "Bacterial Quorum-Sensing Network Architectures". Annual Review of Genetics. 43 (1): 197–222. doi:10.1146/annurev-genet-102108-134304. ISSN 0066-4197. PMC 4313539. PMID 19686078.
  • Bassler, Bonny L.; Losick, Richard (April 2006). "Bacterially Speaking". Cell. 125 (2): 237–246. doi:10.1016/j.cell.2006.04.001. ISSN 0092-8674. PMID 16630813. S2CID 17056045.
  • Camilli, Andrew; Bassler, Fair L. (February 24, 2006). "Bacterial Small-Molecule Signaling Pathways". Science. 311 (5764): 1113–1116. Bibcode:2006Sci...311.1113C. doi:10.1126/science.1121357. ISSN 0036-8075. PMC 2776824. PMID 16497924.
  • Waters, Christopher M.; Bassler, Bonnie L. (November 1, 2005). "Quorum sensing: Cell-to-Cell Communication hold Bacteria". Annual Review of Cell come first Developmental Biology. 21 (1): 319–346. doi:10.1146/annurev.cellbio.21.012704.131001. ISSN 1081-0706. PMID 16212498.
  • Lenz, Derrick H.; Mok, Kenny C.; Lilley, Brendan N.; Kulkarni, Rahul V.; Wingreen, Ned S.; Bassler, Fair L. (July 9, 2004). "The Tiny RNA Chaperone Hfq and Multiple Run down RNAs Control Quorum Sensing in Eubacteria harveyi and Vibrio cholerae". Cell. 118 (1): 69–82. doi:10.1016/j.cell.2004.06.009. ISSN 0092-8674. PMID 15242645. S2CID 18997499.
  • Miller, Melissa B.; Bassler, Bonnie L. (October 1, 2001). "Quorum Sensing in Bacteria". Annual Review of Microbiology. 55 (1): 165–199. doi:10.1146/annurev.micro.55.1.165. ISSN 0066-4227. PMID 11544353.
  • Schauder, Stephan; Shokat, Kevan; Surette, Michael G.; Bassler, Beautiful L. (December 21, 2001). "The LuxS family of bacterial autoinducers: biosynthesis allround a novel quorum-sensing signal molecule". Molecular Microbiology. 41 (2): 463–476. doi:10.1046/j.1365-2958.2001.02532.x. ISSN 0950-382X. PMID 11489131. S2CID 24852124.
  • Surette, Michael G.; Miller, Melissa B.; Bassler, Bonnie L. (February 16, 1999). "Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: Unornamented new family of genes responsible emancipation autoinducer production". Proceedings of the Popular Academy of Sciences. 96 (4): 1639–1644. Bibcode:1999PNAS...96.1639S. doi:10.1073/pnas.96.4.1639. ISSN 0027-8424. PMC 15544. PMID 9990077.
  • Bassler, Bonny L (December 1999). "How bacteria address to each other: regulation of sequence expression by quorum sensing". Current Be of the same mind in Microbiology. 2 (6): 582–587. doi:10.1016/s1369-5274(99)00025-9. ISSN 1369-5274. PMID 10607620.
  • Bassler, Bonnie L.; Wright, Miriam; Silverman, Michael R. (July 1994). "Multiple signalling systems controlling expression of write off in Vibrio harveyi : sequence and r“le of genes encoding a second epicurean pathway". Molecular Microbiology. 13 (2): 273–286. doi:10.1111/J.1365-2958.1994.Tb00422.X. PMID 7984107. S2CID 39587138.
  • Bassler, Bonnie L.; Discoverer, Miriam; Showalter, Richard E.; Silverman, Archangel R. (August 1993). "Intercellular signalling interior Vibrio harveyi: sequence and function commuter boat genes regulating expression of luminescence". Molecular Microbiology. 9 (4): 773–786. doi:10.1111/j.1365-2958.1993.tb01737.x. ISSN 0950-382X. PMID 8231809. S2CID 36357210.

References

  1. ^ ab"Book of Members, 1780–2010: Chapter B"(PDF). American Academy of Music school and Sciences. Archived(PDF) from the basic on October 9, 2022. Retrieved May well 20, 2011.
  2. ^ abcde"Michael Silverman and Fair Bassler win 2021 Paul Ehrlich become calm Ludwig Darmstaedter Prize". EurekAlert!. January 27, 2021. Retrieved February 1, 2022.
  3. ^ ab"Bonnie L. Bassler, Ph.D."Howard Hughes Medical Institute. Archived from the original on May well 16, 2013. Retrieved May 20, 2011.
  4. ^"Bonnie L. Bassler". Princeton University. March 11, 2016.
  5. ^ ab"Bassler awarded Pearl Meister Greengard Prize". Princeton University. November 17, 2016. Retrieved February 1, 2022.
  6. ^ ab"UN viewpoint L'Oreal announce winners of women reconcile science award". United Nations News. Nov 8, 2011. Retrieved February 1, 2022.
  7. ^ ab"Richard Lounsbery Award". National Academy beat somebody to it Sciences. Retrieved March 10, 2017.
  8. ^ ab"Eighth Annual Wiley Prize in Biomedical Sciences Awarded to Dr. Bonnie Bassler authentication Princeton University".
  9. ^ abc"Bonnie Bassler Molecular Zoologist factualist, Class of 2002". MacArthur Foundation. 2002.
  10. ^"Bonnie L. Bassler". National Academy of Sciences. Retrieved September 17, 2021.
  11. ^Staff. "Professor Beautiful L. Bassler ForMemRS". The Royal Fellowship. Retrieved October 21, 2012.
  12. ^ ab"Bonnie Bassler; PhD". American Society for Microbiology. Retrieved February 1, 2022.
  13. ^"Obama to nominate Princeton's Bassler for National Science Board". Princeton University. October 21, 2011. Retrieved Sep 17, 2021.
  14. ^"Daily Digest". Congressional Record. 158 (61). April 26, 2012. Retrieved Sept 17, 2021.
  15. ^"CO-EDITORS OF THE ANNUAL Consider OF GENETICS – VOLUME 46, 2012". Annual Reviews. Retrieved July 29, 2021.
  16. ^"EDITOR OF THE ANNUAL REVIEW OF Genetic make-up – VOLUME 51, 2017". Annual Reviews. Retrieved July 29, 2021.
  17. ^ abcdeAhmed, Farooq (April 1, 2008). "Profile of Beautiful L. Bassler". Proceedings of the State-owned Academy of Sciences. 105 (13): 4969–4971. Bibcode:2008PNAS..105.4969A. doi:10.1073/pnas.0705870105. ISSN 0027-8424. PMC 2278219. PMID 18362352.
  18. ^"Autobiography curst Bonnie L Bassler". The Shaw Prize. Retrieved February 1, 2022.
  19. ^"L'Oreal-UNESCO Names Prof Bonnie Bassler, Princeton University, For Detachment in Science 2012 Laureate for Boreal America". Princeton, New Jersey Patch. Apr 13, 2012. Retrieved February 2, 2022.
  20. ^Schauder, S.; Bassler, B. L. (2001). "The languages of bacteria". Genes & Development. 15 (12): 1468–80. doi:10.1101/gad.899601. PMID 11410527.
  21. ^"Bonnie Bassler". Broad Institute. March 20, 2018. Retrieved May 3, 2019.
  22. ^ ab"Bassler Lab Research". scholar.princeton.edu. Retrieved May 2, 2020.
  23. ^Hmelo, Laura R. (January 3, 2017). "Quorum Wisdom in Marine Microbial Environments". Annual Consider of Marine Science. 9 (1): 257–281. Bibcode:2017ARMS....9..257H. doi:10.1146/annurev-marine-010816-060656. ISSN 1941-1405. PMID 27814032.
  24. ^ ab"Bonnie Bassler receives Gruber Genetics Prize". Princeton University. February 7, 2020. Retrieved February 2, 2022.
  25. ^"Bassler receives Gruber Genetics Prize bring about discoveries on how bacteria communicate". Princeton University. February 7, 2020. Retrieved Feb 2, 2022.
  26. ^Marks, Marilyn (September 25, 2002). "Biologist Bonnie Bassler receives MacArthur Fellowship". Princeton University News.
  27. ^"Elected Fellows". AAAS – The World's Largest General Scientific Society. October 21, 2016. Retrieved March 10, 2017.
  28. ^"Special Recognitions 2008". World Cultural Talking shop parliamen. Retrieved February 1, 2022.
  29. ^"Wiley Foundation Ex- winners".
  30. ^"The Nifty Fifty (times 2)". Army Science and Engineering Festival. 2010. Retrieved February 1, 2022.
  31. ^"National Science Board". National Science Board. Retrieved March 10, 2017.
  32. ^"Bassler Wins L'ORÉAL-UNESCO Award in Life Sciences". National Academy of Sciences. November 8, 2011. Retrieved February 1, 2022.
  33. ^"The Ordinal Annual L'ORÉAL-UNESCO Awards For Women beckon Science Honor Five Exceptional Women Who Move Science Forward". L'Oréal USA. Nov 8, 2011. Retrieved February 1, 2022.
  34. ^Kelly, Morgan (November 8, 2011). "FACULTY AWARD: Bassler to receive L'Oréal-UNESCO For Platoon in Science Award". Princeton University. Retrieved February 1, 2022.
  35. ^"Members | American Scholarly Society". www.amphilsoc.org. Retrieved March 10, 2017.
  36. ^"Princeton's Dr Bonnie Bassler Receives 2014 Spite C. Evans Award". Genomics Research immigrant Technology Networks. May 22, 2014. Retrieved February 1, 2022.
  37. ^"The 2015 Prize exclaim Life Science & Medicine Bonnie Renown. Bassler E. Peter Greenberg". The Bandleader Prize. 2015. Retrieved February 1, 2022.
  38. ^"FASEB 2016 Excellence in Science Award beneficiary announced". EurekAlert!. July 1, 2015. Retrieved February 1, 2022.
  39. ^"AAAS Fellow Bonnie Bassler wins 2016 Max Planck Research Award". American Association for the Advancement spick and span Science. Retrieved October 20, 2018.
  40. ^"National Establishment of Medicine Elects 80 New Employees – National Academy of Medicine". National Academy of Medicine. October 17, 2016. Retrieved October 20, 2018.
  41. ^Webteam, University type Pittsburgh. "2018 Dickson Prize Winner". www.dicksonprize.pitt.edu. Retrieved October 20, 2018.
  42. ^"Ernst Schering Award 2018 goes to Bonnie L. Bassler". Schering Stiftung. 2018. Retrieved February 1, 2022.
  43. ^"People in the News 2018". The Vallee Foundation. Retrieved February 1, 2022.
  44. ^"Congratulations to the recipients of the 2020 GSA Awards!". Genetics Society of U.s.. January 29, 2020. Retrieved February 5, 2020.
  45. ^Mrusek, Marco (January 27, 2021). "Mikrobiologen mit Paul Ehrlich- und Ludwig Darmstaedter-Preis geehrt". AerzteZeitung.de (in German). Retrieved Jan 27, 2021.
  46. ^"Wolf Prize in Chemistry 2022". Archived from the original on Feb 8, 2022. Retrieved February 9, 2022.
  47. ^"Honorary Degrees Awarded".
  48. ^Canada Gairdner International Award 2023
  49. ^Princess of Asturias Awards 2023
  50. ^Albany Medical Soul Prize 2023
  51. ^The White House (January 3, 2025). "President Biden Honors Nation's Hero Scientists, Technologists, and Innovators". The Grey House. Retrieved January 4, 2025.

External links

Laureates of the Prince or Empress of Asturias Award for Technical reprove Scientific Research

Prince of Asturias Award for Technical and Scientific Research

  • 1981: Alberto Sols
  • 1982: Manuel Ballester
  • 1983: Luis Antonio Santaló Sors
  • 1984: Antonio Garcia-Bellido
  • 1985: King Vázquez Martínez and Emilio Rosenblueth
  • 1986: Antonio González González
  • 1987: Jacinto Convit and Pablo Rudomín
  • 1988: Manuel Cardona and Marcos Moshinsky
  • 1989: Guido Münch
  • 1990: Santiago Grisolía and Salvador Moncada
  • 1991: Francisco Bolívar Zapata
  • 1992: Federico García Moliner
  • 1993: Amable Liñán
  • 1994: Manuel Patarroyo
  • 1995: Manuel Losada Villasante and Instituto Nacional shape Biodiversidad of Costa Rica
  • 1996: Valentín Fuster
  • 1997: Atapuerca research team
  • 1998: Emilio Méndez Pérez and Pedro Miguel Echenique Landiríbar
  • 1999: Economist Miledi and Enrique Moreno González
  • 2000: Parliamentarian Gallo and Luc Montagnier
  • 2001: Craig Stomach, John Sulston, Francis Collins, Hamilton Sculptor, and Jean Weissenbach
  • 2002: Lawrence Roberts, Parliamentarian E. Kahn, Vinton Cerf, and Tim Berners-Lee
  • 2003: Jane Goodall
  • 2004: Judah Folkman, Genteel Hunter, Joan Massagué, Bert Vogelstein, topmost Robert Weinberg
  • 2005: Antonio Damasio
  • 2006: Juan Ignacio Cirac
  • 2007: Peter Lawrence and Ginés Morata
  • 2008: Sumio Iijima, Shuji Nakamura, Robert Langer, George M. Whitesides, and Tobin Marks
  • 2009: Martin Cooper and Raymond Tomlinson
  • 2010: Painter Julius, Baruch Minke, and Linda Watkins
  • 2011: Joseph Altman, Arturo Álvarez-Buylla, and Giacomo Rizzolatti
  • 2012: Gregory Winter and Richard Straight. Lerner
  • 2013: Peter Higgs, François Englert, contemporary European Organization for Nuclear Research CERN
  • 2014: Avelino Corma Canós, Mark E. Solon, and Galen D. Stucky

Princess of Asturias Award for Technical arm Scientific Research

  • 2015: Emmanuelle Charpentier elitist Jennifer Doudna
  • 2016: Hugh Herr
  • 2017: Rainer Weiss, Kip S. Thorne, Barry C. Kamarupan, and the LIGO Scientific Collaboration
  • 2018: Svante Pääbo
  • 2019: Joanne Chory and Sandra Myrna Díaz
  • 2020: Yves Meyer, Ingrid Daubechies, Playwright Tao, and Emmanuel Candès
  • 2021: Katalin Karikó, Drew Weissman, Philip Felgner, Uğur Şahin, Özlem Türeci, Derrick Rossi, and Wife Gilbert
  • 2022: Geoffrey Hinton, Yann LeCun, Yoshua Bengio, and Demis Hassabis
  • 2023: Jeffrey Unrestrainable. Gordon, Everett Peter Greenberg, and Beautiful Bassler
  • 2024: Daniel J. Drucker, Jeffrey Lot. Friedman, Joel F. Habener, Jens Juul Holst, and Svetlana Mojsov

Shaw Premium laureates

Astronomy
Life science
and medicine
Mathematical
science